Imepitoin treatment reduces stress levels in anxious dogs

25 Jul 2020

Vet Record Image

B Forster, O Engel, M Erhard and others

Journal of Veterinary Behaviour (2020) 38, 67–73

doi: 10.1016/j.jveb.2020.05.006

• What did the research find?

No difference in anxiety-related behaviour was observed between dogs receiving imepitoin and those receiving a placebo. However, serum cortisol decreased between day 0 and day 3 in the imepitoin-treated dogs (median decrease of 21.1 nmol/l) while it increased in placebo-treated dogs (median increase of 11.6 nmol/l). The change in serum cortisol between treatment days was greater in dogs with more severe anxiety (P<0.001). The owners of the imepitoin-treated dogs reported a slight improvement in anxious behaviour at home, but this difference was not statistically significant.

• How was it conducted?

A total of 60 dogs with generalised anxiety disorder (GAD) were enrolled in the study and underwent a behavioural test to determine the severity of their anxiety. Blood samples were also taken to measure serum cortisol...